Free Tools
Free Research Tools
94 free, open-access tools built for systematic review and meta-analysis researchers. Every export is clean and publication-ready. No sign-up, no watermarks, no paywalls.
PRISMA & Study Selection
Free Tool
PRISMA Flow Generator
Generate a PRISMA 2020-compliant flow diagram in seconds. Enter your identification, screening, and inclusion numbers and download a publication-ready diagram as a high-resolution PNG.
Features
PRISMA 2020 compliant
Real-time preview
PNG export
Pre-filled examples
Free Tool
Criteria Builder
Build structured eligibility criteria using the PICOS framework. Define population, intervention, comparator, outcome, and study design parameters, then export a formatted criteria table.
Features
PICOS framework
Structured output
Copy to clipboard
Export-ready
Free Tool
Search Builder
Construct Boolean search strings for PubMed, Cochrane, and Embase from plain-language inputs with synonym expansion and field tag support.
Features
Multi-database support
MeSH terms
Boolean operators
Copy to clipboard
Free Tool
Search Translator
Convert a search string from one database syntax to another. Supports PubMed, Embase, CINAHL, Cochrane, Web of Science, Scopus, and PsycINFO.
Features
7 databases
Syntax mapping
Field tag conversion
Wildcard translation
Free Tool
PRISMA-ScR Checklist
Interactive PRISMA-ScR checklist for scoping reviews with 22 items. Track completion, add notes, and export your compliance summary.
Features
22-item checklist
Progress tracking
Notes per item
CSV export
Risk of Bias & Quality Assessment
Free Tool
RoB 2 Tool
Create Risk of Bias (RoB 2) traffic light tables with robvis-style summary bar charts. Add studies, cycle through domain-level judgments, view domain summaries, and export everything as publication-ready PNG images.
Features
RoB 2 domains
Traffic light display
Summary bar chart
Domain summaries
PNG export
Autosave
Free Tool
ROBINS-I Tool
Assess risk of bias in non-randomized studies using the ROBINS-I framework with 7 bias domains, traffic-light visualization, and robvis-style summary bar charts showing distribution across judgment levels.
Features
7 bias domains
Traffic light display
Summary bar chart
Multi-study support
PNG export
Autosave
Free Tool
ROBINS-E Tool
Assess risk of bias in non-randomized studies of exposures using the ROBINS-E framework with 7 bias domains, traffic-light visualization, and robvis-style summary bar charts for environmental and occupational epidemiology.
Features
7 exposure bias domains
Traffic light display
Summary bar chart
Weighted bars
Multi-study support
PNG export
Autosave
Free Tool
QUADAS-2
Assess risk of bias and applicability concerns in diagnostic test accuracy studies using the QUADAS-2 framework (Whiting et al., 2011). Four domains with signaling questions, robvis-style summary charts, and weighted bars.
Features
4 RoB domains + 3 Applicability
Click-to-cycle judgments
Signaling questions
Weighted summary bars
robvis-style charts
PNG export
Multi-study support
DTA-specific
Free Tool
QUIPS
Assess risk of bias in prognostic factor studies using the QUIPS framework (Hayden et al., 2013). Six domains covering participation, attrition, prognostic factor measurement, outcome measurement, confounding, and statistical analysis.
Features
6 QUIPS domains
Click-to-cycle judgments
Summary bar chart
Weighted bars
PNG export
Multi-study support
Prognostic-specific
Free Tool
NOS Calculator
Interactive Newcastle-Ottawa Scale scoring for cohort and case-control studies with star-based scoring and domain breakdowns.
Features
Cohort & case-control
Star scoring
Domain breakdown
Multi-study support
Free Tool
GRADE Tool
Walk through the GRADE framework to rate certainty of evidence. Assess risk of bias, inconsistency, indirectness, imprecision, and publication bias, then generate a Summary of Findings table.
Features
5 GRADE domains
Upgrading factors
SoF table
Export-ready
Free Tool
AMSTAR-2
Assess the methodological quality of systematic reviews using the AMSTAR-2 framework (Shea et al., 2017). 16 items with 7 critical domains, auto-calculated confidence ratings (High, Moderate, Low, Critically Low), summary bar charts, and publication-ready PNG export. Essential for umbrella reviews and overviews of reviews.
Features
16 AMSTAR-2 items
7 critical domain markers
Auto-calculated confidence rating
Click-to-cycle judgments
Summary bar chart
PNG export
Multi-review support
Autosave
Free Tool
JBI Checklist
Interactive JBI critical appraisal checklists across multiple study designs including RCTs, cohort, cross-sectional, qualitative, and prevalence studies.
Features
Multiple study designs
Scoring system
Multi-study
CSV export
Meta-Analysis & Statistical Calculators
Free Tool
Effect Size Calc
Calculate and convert between common effect size measures: Cohen’s d, Hedges’ g, odds ratios, risk ratios, and correlation coefficients. Central hub of the analysis pipeline—compute effect sizes from raw data or test statistics, then send results directly to forest plot, funnel plot, or heterogeneity tools.
Features
SMD, OR, RR, r
Batch CSV/Excel import
Pipeline to forest & funnel
From t/F/χ²/p conversion
Free Tool
Heterogeneity Calc
Assess heterogeneity with I², Cochran’s Q, τ², and prediction intervals using DerSimonian-Laird and REML estimators. Import studies directly from the pipeline for seamless meta-analysis workflow.
Features
I² & Cochran’s Q
REML τ² estimator
Pipeline import
CSV/Excel import
Free Tool
Forest Plot
Create publication-ready forest plots with subgroup analysis, cumulative meta-analysis, Galbraith and Baujat diagnostic plots, REML and DerSimonian-Laird estimators, prediction intervals, R code generation, and leave-one-out sensitivity testing. Selectable confidence levels (80%, 90%, 95%, 99%).
Features
Subgroup analysis
Cumulative meta-analysis
Galbraith & Baujat plots
REML estimator
Prediction intervals
R code (metafor)
Leave-one-out sensitivity
Methods text generator
Copy plot to clipboard
CSV/Excel import
Free Tool
Multilevel Meta-Analysis
Fit three-level random-effects meta-analysis with REML for dependent effect sizes nested within studies or clusters. Partitions heterogeneity into between-cluster and within-cluster variance, reports the intraclass correlation, and adds cluster-robust (RVE) confidence intervals. Exports metafor rma.mv and clubSandwich R code.
Features
Three-level random-effects model
REML variance components
Between and within-cluster tau-squared
Intraclass correlation (ICC)
Cluster-robust (RVE) intervals
Meta-regression moderator
Cochran's Q and I-squared
R code (rma.mv + clubSandwich)
Methods text generator
Free Tool
Funnel Plot
Generate contour-enhanced funnel plots with Egger's regression, Begg's rank test, trim-and-fill analysis, and fail-safe N (Rosenthal, Orwin, Rosenberg). Selectable confidence levels, R code generation, and auto-generated methods paragraphs for publication.
Features
Contour-enhanced plot
Egger's & Begg's tests
Trim-and-fill
Fail-safe N (3 methods)
R code (metafor)
Methods text generator
Copy plot to clipboard
Pipeline import
Free Tool
Relative Risk Calc
Compute the relative risk (risk ratio) from a 2x2 contingency table or events-and-totals, with log-Wald confidence intervals, p-value, absolute risk difference, NNT, and Zhang-Yu (1998) OR-to-RR conversion. Haldane-Anscombe correction for zero cells. Exports R, Python, and APA write-up.
Features
2x2 table, events/totals, or OR-to-RR
Log-Wald CI (80/90/95/99)
Zhang-Yu (1998) conversion
Companion ARD, NNT, OR
Haldane-Anscombe correction
R, Python, APA export
Free Tool
Odds Ratio Calc
Compute the odds ratio from a 2x2 contingency table with log-Wald confidence intervals, p-value, relative risk, absolute risk difference, NNT, and Haldane-Anscombe continuity correction. Exports R, Python, and APA write-up.
Features
2x2 table or events/totals
Log-Wald CI (80/90/95/99)
Companion RR, ARD, NNT
Haldane-Anscombe correction
R, Python, APA export
Free Tool
NNT Calculator
Convert between odds ratios, risk ratios, absolute risk reduction, and number needed to treat. Enter any measure with baseline risk to compute all others.
Features
OR/RR/ARR/NNT
Baseline risk input
Bidirectional conversion
Copy results
Free Tool
Meta-Regression
Structure moderator data for meta-regression analysis. Validate and format study-level data for export to R (metafor), Stata, or Comprehensive Meta-Analysis.
Features
Moderator variables
Data validation
Multi-format export
Template builder
Free Tool
Sensitivity Analysis
Perform leave-one-out sensitivity analysis with D3-powered visualization showing how each study impacts the pooled estimate. Selectable confidence levels, copy plot to clipboard, auto-generated methods paragraphs, and high-resolution PNG/SVG export.
Features
Leave-one-out
D3 forest-style plot
Copy plot to clipboard
Methods text generator
Selectable CI levels
PNG & SVG export
Free Tool
P-Curve Analysis
Evaluate whether significant findings contain evidential value or show signs of p-hacking using p-curve analysis (Simonsohn et al., 2014). Binomial and continuous right-skew tests, flatness test against 33% power, D3.js histogram, R code for dmetar, and auto-generated methods text.
Features
P-value input or t/F/χ²/z conversion
Binomial right-skew test
Stouffer continuous test
Flatness test vs 33% power
D3.js p-curve histogram
R code (dmetar)
Methods text
CSV import/export
Free Tool
Doi Plot + LFK
Generate Doi plots with LFK index for detecting publication bias in meta-analyses, especially with fewer than 10 studies. Superior statistical power compared to funnel plots and Egger's test (Furuya-Kanamori, Barendregt & Doi, 2018).
Features
Doi plot (normal quantile vs Z-score)
LFK index with interpretation
Asymmetry shading
Identity line reference
D3.js interactive plot
R code generation
Methods text
CSV import/export
Free Tool
DTA Calculator
Compute sensitivity, specificity, positive and negative predictive values, likelihood ratios, and diagnostic odds ratio from a 2×2 contingency table.
Features
2×2 table input
Sensitivity/Specificity
LR+/LR−
DOR & Youden’s J
Free Tool
Bayes Factor Calc
Compute Bayes factors for common test scenarios including one-sample and two-sample t-tests, correlations, and proportions with interpretation guidelines.
Features
Multiple test types
BF10 & BF01
Interpretation scale
Jeffreys’ guidelines
Free Tool
Proportion MA
Pool single-group proportions (prevalence, complication rates, response rates) across studies using raw, logit, Freeman-Tukey double arcsine, or arcsine square root transformations with fixed or random-effects models.
Features
4 transformations
DerSimonian-Laird
Forest plot
Prediction interval
Free Tool
L'Abbe Plot
Generate L'Abbe plots (L'Abbe et al., 1987) to visualize treatment vs control event rates in binary outcome meta-analyses. Bubble sizing by sample size, diagonal no-effect line, optional constant risk ratio reference lines, and heterogeneity detection.
Features
Binary outcome scatter
Bubble sizing by N
Constant RR lines
D3.js interactive
R code generation
Methods text
CSV import
PDF/PNG export
Free Tool
GOSH Plot
Generate GOSH plots (Olkin et al., 2012) for all-subsets heterogeneity analysis. Visualize how pooled effect and I-squared vary across all possible study combinations to identify influential outliers and heterogeneity drivers.
Features
All-subsets analysis
Study highlighting
Batched computation
D3.js scatter
R code (metafor::gosh)
Methods text
CSV import
PDF/PNG export
Free Tool
Bubble Plot
Generate bubble plots for meta-regression visualization (Thompson & Higgins, 2002). Plot study effect sizes against moderator values with precision-weighted bubbles, WLS regression line, and 95% CI band.
Features
WLS regression
Precision-weighted bubbles
CI band
Custom covariate label
R code (metafor::regplot)
Methods text
CSV import
PDF/PNG export
Free Tool
ES Converter
Convert between effect size types: Cohen's d to Odds Ratio, d to correlation r, OR to r, RR to OR, d to eta-squared, and more. Based on Borenstein et al. (2009) and Chinn (2000) formulas with SE propagation.
Features
10 conversion directions
SE propagation
Batch mode
CI construction
R code
Methods text
Pipeline send
CSV import
Free Tool
TSA
Perform Trial Sequential Analysis with alpha-spending monitoring boundaries (O'Brien-Fleming), Required Information Size calculation, cumulative Z-curve, and futility boundaries. Based on Wetterslev et al. (2008).
Features
O'Brien-Fleming boundaries
Required Information Size
Cumulative Z-curve
Futility boundaries
Binary + continuous
D3.js TSA diagram
R code
PDF/PNG export
Free Tool
NMA Helper
Build network meta-analysis diagrams, validate network geometry, generate league tables, and format data for R netmeta, WinBUGS, and STATA. Force-directed D3.js network visualization with connectivity checking.
Features
Force-directed network diagram
League table
Connectivity check
R netmeta format
WinBUGS format
STATA format
D3.js interactive
Methods text
Free Tool
MH / Peto
Pool dichotomous data using Mantel-Haenszel fixed-effect method (OR, RR, RD) or Peto Odds Ratio for rare events. Direct 2x2 table input with zero-cell correction, forest plot, and heterogeneity assessment.
Features
MH-OR / MH-RR / MH-RD
Peto OR for rare events
Zero-cell correction
D3 forest plot
Heterogeneity stats
R code (rma.mh/rma.peto)
Methods text
CSV import
Free Tool
Fagan Nomogram
Interactive Fagan nomogram for diagnostic test interpretation. Enter pre-test probability with sensitivity and specificity, direct likelihood ratios, or a 2x2 contingency table. Visualize the classic three-scale nomogram showing post-test probabilities for positive and negative test results.
Features
D3.js three-scale nomogram
Sensitivity/Specificity input
Direct LR+/LR- input
2x2 table input
Post-test probability
R code generation
Methods text
PNG/PDF export
Free Tool
SROC Curve
Generate summary receiver operating characteristic curves for diagnostic test accuracy meta-analysis. Enter sensitivity and specificity pairs from multiple studies, fit the Moses-Littenberg model, and plot study points as weighted bubbles with the fitted SROC curve, AUC, and Q* index.
Features
D3.js ROC space
Weighted study bubbles
Moses-Littenberg SROC curve
AUC calculation
Q* index
Sens/Spec or 2x2 input
R code (mada)
Methods text
PNG/PDF export
CSV import
Free Tool
Selection Model
Assess publication bias using Vevea-Hedges weight-function selection models. Compare unadjusted random-effects estimates against selection-adjusted estimates across moderate and severe one-tailed and two-tailed weight patterns. Sensitivity analysis with D3.js visualizations.
Features
Step-function weights
Moderate/severe selection
One-tailed/two-tailed
Comparison forest plot
Weight function chart
R code (weightr)
Methods text
PNG/PDF export
CSV import
Pipeline import
Free Tool
Distribution of Effects
Visualize the estimated distribution of true effect sizes in a random-effects meta-analysis. Plot the Normal(mu, tau-squared) density curve, prediction intervals, study effect marks, histogram overlay, and compute the probability that the true effect exceeds any threshold. DerSimonian-Laird estimation with R code and methods paragraph export.
Features
Normal density curve
Prediction interval
Threshold probability
Histogram overlay
Tau/I²/Q statistics
Configurable CI level
R code (metafor + dnorm)
Methods paragraph
PNG/PDF export
CSV import
Pipeline import
Biostatistics Utilities
Free Tool
Logistic Regression
Fit a binary logistic regression in the browser by iteratively reweighted least squares. Paste an outcome column plus numeric predictors and get coefficients, odds ratios with 95% CI, Wald p-values, the likelihood-ratio test, McFadden R-squared, and AIC. Detects separation. Fit matches statsmodels; R, Python, and APA export.
Features
IRLS maximum-likelihood fit
Odds ratios with 95% CI
Multiple predictors
Likelihood-ratio test + McFadden R²
Separation detection
APA Word + CSV export
R + Python code
Free Tool
Table 1 Generator
Paste or upload a dataset and get a publication-ready baseline characteristics table (Table 1). Detects continuous vs categorical variables, summarizes each by group as mean (SD), median [IQR], or n (%), runs the correct group-comparison test (t-test, ANOVA, Mann-Whitney, Kruskal-Wallis, chi-square, or Fisher's exact), and exports an APA-formatted Word table.
Features
Auto continuous vs categorical detection
Mean (SD), median [IQR], n (%)
Auto test selection + p-values
Skew-aware median switch
APA Word + Excel + CSV export
CSV / Excel import
Free Tool
Test Selector
Answer a few questions about your outcome, groups, and design and get the right statistical test with its assumptions, the non-parametric or exact alternative, and a direct link to the free calculator that runs it. Covers t-tests, ANOVA, chi-square, Fisher's exact, correlation, regression, McNemar, kappa, ICC, and Cronbach's alpha.
Features
Guided decision tree
Assumption checklist per test
Non-parametric + exact alternatives
Direct links into 15+ calculators
Paired vs independent logic
Small-sample routing to exact tests
Free Tool
McNemar Test
Run the McNemar test on paired binary data with asymptotic chi-square, Yates continuity correction, exact binomial and mid-p p-values, Newcombe Method 10 95% CI for the paired difference in proportions, conditional odds ratio with log-Wald CI, Cohen's kappa, plus McNemar-Bowker symmetry and Stuart-Maxwell marginal homogeneity tests for k × k tables. Reproducible R, Python, and APA output.
Features
Asymptotic + Yates + exact + mid-p p-values
Newcombe Method 10 paired RD 95% CI
Conditional OR with log-Wald CI
Cohen's kappa for paired agreement
McNemar-Bowker symmetry for k × k
Stuart-Maxwell marginal homogeneity
R + Python + APA + CSV export
Free Tool
Cronbach's α
Compute Cronbach's α (raw and standardised) for scale reliability with Feldt and Bonett 95% confidence intervals, McDonald's ω, Guttman's λ₆, Spearman-Brown split-half reliability, item-total correlations, and α-if-item-deleted. Three input modes (raw data, correlation matrix, or summary statistics) with reproducible R, Python, and APA output.
Features
Raw and standardised α
Feldt + Bonett 95% CIs
McDonald's ω + Guttman's λ₆
Item-total r + α-if-deleted
Spearman-Brown split-half
R + Python + APA + CSV export
Free Tool
Kruskal-Wallis
Run the Kruskal-Wallis H test (non-parametric one-way ANOVA) on three or more independent groups with ties-corrected H, chi-square p-value, epsilon-squared and eta-squared effect sizes, and Dunn's post-hoc with Bonferroni / Holm / Sidak adjustment. Also covers the Friedman test for repeated measures and the Jonckheere-Terpstra trend test. Reproducible R, Python, and APA output.
Features
Ties-corrected H statistic
Epsilon² + eta² + Kendall's W effect sizes
Dunn's post-hoc (Bonferroni / Holm / Sidak)
Friedman repeated-measures mode
Jonckheere-Terpstra trend test
R + Python + APA + CSV export
Free Tool
Mann-Whitney U
Run the Mann-Whitney U (Wilcoxon rank-sum) test on two independent groups with exact and asymptotic ties-corrected p-values, rank-biserial r, Cliff's delta, common-language effect size, and the Hodges-Lehmann median with 95 percent confidence interval. Also covers the Wilcoxon signed-rank test for paired data and the Brunner-Munzel test under unequal variances. Reproducible R, Python, and APA output.
Features
Exact + asymptotic p-values
Ties-corrected variance + continuity correction
Rank-biserial r, Cliff's delta, CLES
Hodges-Lehmann median + 95% CI
Wilcoxon signed-rank for paired data
Brunner-Munzel for heteroscedastic shapes
R + Python + APA + CSV export
Free Tool
Fisher's Exact
Run Fisher's exact test on 2 × 2 and r × c contingency tables with two-sided and one-sided exact p-values, mid-p adjustment, odds ratio with exact 95% confidence interval, and Barnard's and Boschloo's unconditional exact tests. Reproducible R, Python, and APA output for small-sample categorical data.
Features
2×2 conditional Fisher + mid-p
One-sided and two-sided exact p
Odds ratio + risk ratio + ARD + NNT
Barnard + Boschloo unconditional exact
Fisher-Freeman-Halton Monte Carlo r×c
R + Python + APA export
Free Tool
ANOVA Calc
Run one-way, two-way factorial, and repeated-measures analysis of variance in your browser. Returns the full sources-of-variance table, F-statistic, p-value, eta-squared, omega-squared, partial eta-squared, Cohen's f, Welch's correction for unequal variances, Bonferroni / Holm / Sidak post-hoc pairwise tests, and Greenhouse-Geisser plus Huynh-Feldt sphericity-corrected p-values with reproducible R, Python, and APA output.
Features
One-way + two-way + repeated measures
Welch's ANOVA for unequal variances
Eta² / partial η² / omega² / Cohen's f
Bonferroni + Holm + Sidak pairwise
Greenhouse-Geisser + Huynh-Feldt sphericity correction
R + Python + APA + CSV export
Free Tool
Binomial Calc
Compute P(X = k), P(X ≤ k), P(X ≥ k), and between-bounds probabilities from a binomial distribution. Run an exact one-sample binomial test and build Clopper-Pearson, Wilson, Agresti-Coull, or Wald 95 percent confidence intervals for a proportion, with reproducible R, Python, and APA output.
Features
PMF, CDF, and survival probabilities
Six probability kinds (=, <, ≤, >, ≥, between)
Exact one-sample binomial test
Clopper-Pearson, Wilson, Agresti-Coull, Wald CIs
Full PMF / CDF table for k = 0..n
R + Python + APA export
Free Tool
Variance Calc
Compute sample variance, population variance, standard deviation, coefficient of variation, pooled variance, and the chi-square 95 percent confidence interval from raw data or summary statistics. Includes an F-test for equal variances and reproducible R, Python, and APA output.
Features
Sample + population variance
Coefficient of variation
Pooled variance for two samples
Chi-square 95% CI for σ²
F-test for equal variances
R + Python + APA export
Free Tool
Z-Score Calc
Convert a raw value or sample mean into a z-score, look up the corresponding percentile and p-value, and translate between z and IQ, T, SAT, GRE, or any custom scale. Includes a built-in one-sample z-test and reproducible R, Python, and APA output.
Features
Raw value + sample mean modes
z ↔ percentile (inverse normal)
One-sample z-test with SE
IQ / T / SAT / GRE / stanine conversion
R + Python + APA export
Free Tool
P-Value Calc
Convert a z, t, chi-square, F, or Pearson correlation test statistic into a p-value with two-tailed or one-tailed options. Returns critical values at α = 0.05, 0.01, and 0.001 alongside reproducible R, Python, and APA-formatted output.
Features
z, t, χ², F, r distributions
Two-tailed and one-tailed
Critical values at α = 0.05/0.01/0.001
APA results sentence
R + Python export
Free Tool
P-value to CI
Back-calculate confidence intervals from reported p-values, t-statistics, chi-square values, or z-scores. Reconstruct CIs and send results to forest plot, funnel plot, or heterogeneity tools via the analysis pipeline.
Features
From p/t/χ²/z values
CI reconstruction
Pipeline send-to
Excel/CSV export
Free Tool
CI Calculator
Compute 80, 90, 95, or 99 percent confidence intervals for means, proportions, mean differences, proportion differences, odds ratios, and risk ratios. Wilson, Newcombe, and log-Wald methods with reproducible R code export.
Features
Mean / proportion / OR / RR
Wilson + Newcombe methods
Continuity correction for sparse 2x2
R code export
Free Tool
Regression Calculator
Run simple and multiple ordinary least squares regression in your browser. Returns coefficients with standard errors, t-statistics, p-values, and 95 percent confidence intervals alongside R squared, adjusted R squared, F-test, RMSE, residual diagnostics, and R, Python, or APA reporting export.
Features
Simple + multiple OLS
Coefficient table with 95% CI
Residual + scatter diagnostics
R / Python / APA code export
Free Tool
T-Test Calculator
Independent-samples t-test from summary statistics or raw data. Welch and Student variants, two- and one-tailed alternatives. Returns t, df, p-value, confidence interval for the mean difference, Cohen's d, Hedges' g, and R, Python, and APA write-up export.
Features
Welch + Student variants
Summary stats or raw data
t, df, p, CI, Cohen's d, Hedges' g
R / Python / APA export
Free Tool
Survival Digitizer
Guide extraction of time-to-event data from Kaplan-Meier curves. Enter time points and at-risk numbers to estimate hazard ratios and median survival times.
Features
KM data extraction
HR estimation
Tierney/Parmar methods
Export-ready
Free Tool
Correlation Calc
Compute Pearson r, Spearman ρ, and Kendall τ-b from paired raw data or from a known r and n. Returns r², t-statistic, p-value, and Fisher z 95% confidence interval with R, Python, and APA-formatted output.
Features
Pearson + Spearman + Kendall τ-b
Raw paired data or r and n
r² + t + p + 95% Fisher z CI
Two- and one-tailed tests
R / Python / APA export
Free Tool
r to d Converter
Convert between Pearson r, r², Cohen’s d, odds ratios, and other effect metrics with the exact formulas displayed for each conversion.
Features
Bidirectional conversion
Formula display
6 effect metrics
Copy results
Free Tool
SE/SD Converter
Convert between standard deviation, standard error, confidence intervals, and sample size. Provide any two known values to derive the rest.
Features
SD/SE/CI/N conversion
Bidirectional
Instant results
Copy to clipboard
Free Tool
Median to Mean
Estimate mean and standard deviation from median, interquartile range, and sample size using validated methods by Wan et al. (2014), Luo et al. (2018), McGrath et al. (2020), and Hozo et al. (2005). Batch-process multiple studies and send results to the effect size calculator.
Features
Wan/Luo/Hozo methods
Batch CSV/Excel import
Pipeline to effect size
Method comparison
Free Tool
Chi-Square Calc
Analyze contingency tables with Pearson’s chi-square test, Yates’ continuity correction, expected counts, Cramér’s V, and phi coefficient. For exact testing on sparse cells switch to the Fisher’s exact test calculator.
Features
Pearson chi-square + Yates
Cramér’s V & phi
Expected counts
Effect sizes
Free Tool
Power Analysis
Compute required sample sizes for t-tests, ANOVA, chi-square tests, correlations, and regression. Solve for sample size, power, or effect size given the other parameters.
Features
5 test types
Solve any parameter
Power curves
Preset conventions
Free Tool
ICC Calculator
Compute intraclass correlation coefficients from rater data. Supports all six ICC forms: ICC(1,1), ICC(2,1), ICC(3,1), ICC(1,k), ICC(2,k), and ICC(3,k).
Features
All 6 ICC forms
Rater data matrix
CI estimation
Interpretation guide
Protocol & Reporting Helpers
Free Tool
PROSPERO Formatter
Structure your systematic review protocol into PROSPERO submission format. Guided form matching all PROSPERO registration fields with formatted output ready to paste.
Features
All PROSPERO fields
Guided form
Copy-ready output
Validation checks
Free Tool
Extraction Builder
Build a customized data extraction form with 60+ pre-built fields covering study info, population, intervention, outcomes, and risk of bias. Export as a CSV spreadsheet.
Features
60+ pre-built fields
Custom fields
Reorderable columns
CSV export
Free Tool
Synthesis Matrix
Build a synthesis matrix for narrative, thematic, or mixed-methods reviews. Rows = studies, columns = themes. Six review-type presets (intervention, qualitative, mixed, CFIR, diagnostic, prognosis). Markdown and CSV export, auto-saved in your browser.
Features
6 review-type presets
Cross-study comparison grid
Auto-save in browser
Markdown and CSV export
Free Tool
PICO Builder
Convert research questions into structured PICO, PECO, or SPIDER frameworks. Add synonyms for each element and generate a Boolean search string for database searching.
Features
PICO/PECO/SPIDER
Synonym support
Boolean search string
Copy to clipboard
Free Tool
Deduplication Tool
Find and remove duplicate citations from exported library files. Upload RIS, BibTeX, or CSV files for fuzzy matching on title, DOI, author, and year.
Features
RIS/BibTeX/CSV
Fuzzy matching
Review & confirm
Export cleaned file
Free Tool
Kappa Calculator
Compute inter-rater agreement for screening decisions using Cohen’s kappa. Enter a 2×2 or multi-category agreement matrix to get kappa, standard error, 95% CI, and interpretation.
Features
2×2 & multi-category
SE & 95% CI
Po & Pe values
Landis-Koch scale
Free Tool
AI Lit Review Generator
Outline your literature review from a research question, three to six themes, and tagged source papers. The structural half of an AI literature review workflow. Pairs with Elicit, Consensus, Scite. Markdown export in APA, AMA, Vancouver, Harvard, Chicago.
Features
Thesis, journal, or grant outlets
Themed body sections
5 citation styles
Markdown copy + download
Free Tool
Report Generator
Generate a publication-ready methods section for systematic reviews and meta-analyses. Select your methodology choices across 12 categories and get an assembled methods paragraph following PRISMA 2020 reporting standards.
Features
12 methodology sections
Live paragraph generation
PRISMA 2020 aligned
One-click copy
Word count
Autosave
Free Tool
Research Question Generator
Build a structured research question using PICO, PICOS, SPIDER, PEO, PIRD, CoCoPop, or CIMO. Returns a one-sentence question, a component breakdown, and an operationalisation checklist for protocols, theses, and grant applications.
Features
7 frameworks (PICO, PICOS, SPIDER, PEO, PIRD, CoCoPop, CIMO)
Component breakdown
Operationalisation checklist
Markdown export
Free Tool
Thesis Statement Generator
Build a defensible one-sentence thesis statement across argumentative, analytical, expository, comparative, causal, and evaluative stances. Returns multiple phrasings with notes on when each variant fits and a checklist for locking your thesis statement.
Features
6 stances
Multiple phrasings per stance
Locking checklist
Markdown export
Free Tool
Citation Generator
Build a reference list and matching in-text citations in Vancouver, APA, AMA, Harvard, MLA, or Chicago. Import sources by DOI or PubMed ID, then export BibTeX and RIS for your reference manager.
Features
6 citation styles
In-text + reference list
DOI & PMID import
BibTeX & RIS export
Free Tool
Reviewer Response Letter
Paste reviewer comments and build a point-by-point response letter. Numbered comments split automatically, each response opens with proven phrasing for agreement, clarification, additional analysis, or respectful disagreement, and the finished letter exports to a submission-ready Word document.
Features
Auto-splits numbered comments
5 response types with proven openers
Per-comment changes-made log
Multiple reviewers
Worked example letter
Free copy + Word export
Free Tool
Reference Checker
Verify that cited references actually exist. Paste a reference list or BibTeX and each citation is checked against Crossref and PubMed, flagging entries that cannot be located, metadata mismatches, and retracted papers.
Features
Crossref + PubMed lookup
Retraction and concern flags
BibTeX and numbered-list input
Free on-screen verdicts
CSV and Word verification report
Bioinformatics & Sequence Tools
Free Tool
Reverse Complement
Paste a DNA or RNA sequence and get the reverse complement, complement, or reverse strand instantly. Handles FASTA, IUPAC ambiguity codes, case, and RNA output, with copy and FASTA download.
Features
DNA and RNA
IUPAC codes
FASTA input
Copy and download
Free Tool
GC Content
Paste one or many DNA or RNA sequences and get GC content, AT content, GC skew, base composition, and a sliding-window GC plot. FASTA and multi-sequence supported, with CSV export.
Features
GC and AT content
GC skew
Sliding-window plot
Multi-FASTA
Free Tool
DNA Translation
Translate a DNA or RNA sequence across all six reading frames using the standard genetic code. Finds the longest open reading frame, marks stop codons, and copies the protein.
Features
Six-frame translation
Open reading frames
Standard genetic code
Copy protein
Free Tool
Primer Tm
Compute primer melting temperature with the SantaLucia nearest-neighbor model and salt correction. Batch-calculate many primers with GC content, thermodynamics, and comparison formulas.
Features
Nearest-neighbor Tm
Salt correction
Batch primers
CSV export
Free Tool
Venn Diagram
Compare 2, 3, or 4 lists and get overlaps, unique members, and exact region counts. Built for gene lists and any set comparison, with a downloadable SVG diagram and full intersection table.
Features
Up to 4 sets
Exact region counts
Member lists
SVG download
Free Tool
Dot Plot
Compare two DNA sequences or one against itself to reveal shared regions, tandem and inverted repeats, and indels. Adjustable word size, reverse-strand matches, and SVG download.
Features
Sequence comparison
Self dot plot
Reverse-strand matches
SVG download
Free Tool
FDR Calculator
Paste p-values and get Benjamini-Hochberg, Bonferroni, and Benjamini-Yekutieli adjusted values matching R's p.adjust. See how many tests stay significant at any false discovery rate threshold.
Features
Benjamini-Hochberg
Bonferroni and BY
Matches R p.adjust
CSV export
Free Tool
Log2 Fold Change
Paste control and treatment values and get log2 fold change, linear fold change, and direction of regulation for every gene, with a pseudocount option and CSV export.
Features
log2 and linear fold change
Pseudocount option
Direction of regulation
CSV export
Free Tool
RNA-Seq Normalization
Paste raw counts and gene lengths to get CPM, FPKM, and TPM with the correct formulas, so TPM sums to the same total in every sample. CSV export.
Features
CPM, FPKM, TPM
Correct per-sample totals
Gene-length aware
CSV export
Free Tool
Correlation Matrix
Paste a data table and get a colored Pearson or Spearman correlation matrix with every pairwise coefficient. Download the heatmap as an SVG and export a CSV.
Features
Pearson and Spearman
Colored heatmap
Every pairwise coefficient
SVG and CSV export
Free Tool
Volcano Plot
Paste log2 fold change and p-values to plot significance against effect size, threshold on the false discovery rate, label the top genes, and download a publication-ready SVG.
Features
Significance vs effect size
FDR thresholding
Gene labels
SVG and CSV export
Free Tool
Heatmap
Paste an expression matrix and get a clustered, z-scored heatmap with hierarchical clustering of rows and columns. Download a publication-ready SVG.
Features
Hierarchical clustering
Per-row z-score
Row and column ordering
SVG download
Free Tool
PCA Plot
Paste a data matrix and get a principal component analysis scores plot with the variance explained per component, samples colored by group, and a downloadable SVG.
Features
PC1 vs PC2 scores plot
Variance explained
Group coloring
SVG download
Free Tool
Kaplan-Meier
Paste survival data with censoring and get product-limit survival curves, median survival, censoring marks, and a log-rank test between two groups. Download a publication-ready SVG.
Features
Product-limit estimator
Censoring marks
Median survival
Log-rank test
Nursing & Clinical Documentation
Free Tool
SOAP Note Generator
Build a clean, structured SOAP note (Subjective, Objective, Assessment, Plan) for nursing, primary care, mental health, or physical therapy. Worked examples, vital-sign entry, and Word export.
Features
4 note templates
Vital-sign entry
Worked examples
Word export
Free Tool
Care Plan Generator
Build a NANDA-I nursing care plan: a PES diagnosis statement, measurable NOC goals, NIC interventions with rationale, and evaluation. Ships with worked plans for common diagnoses. Word export.
Features
NANDA-I PES format
10 worked diagnoses
Rationale column
Word table export
External Resources We Recommend
Trusted tools and references from the evidence synthesis community.
Cochrane Handbook
The definitive guide to systematic review methodology for health interventions.
PROSPERO Registry
International registry for systematic review protocols in health and social care.
PRISMA Statement
Official PRISMA 2020 checklist, flow diagram templates, and explanation documents.
Covidence
Web-based screening and data extraction platform widely used in systematic reviews.
RevMan
Cochrane’s free software for preparing and maintaining systematic reviews.
RoB 2 Tool
The revised Cochrane risk-of-bias tool for randomized trials with domain-level assessments.
Tools Save Time. Expertise Saves More.
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